Preparation and Pharmaceutical Quality Evaluation of Nattokinase Immunoliposomes and Its Lyophilized Product
- VernacularTitle:纳豆激酶免疫脂质体及其冻干品的制备及药剂学性质评价
- Author:
Gonglong YU
;
Zongning YIN
;
Xia ZHANG
- Publication Type:Journal Article
- Keywords:
Nattokinase;
Immunoliposomes;
Lyophilized product;
Evaluation
- From:
China Pharmacy
1991;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To prepare nattokinase immunoliposomes and its lyophilized product and to evaluate its pharmaceutical quality. METHODS: Nattokinse liposomes were prepared by film dispersion method, then the immunoliposomes were prepared by carbodiimide method coupled anti-human fibrin D-dimer monoclone antibody SZ-63 and lyophilized and evaluated about its pharmaceutical quality. RESULTS: Lyophilized immunoliposomes were multilamellar vesicles with its mean diameter, Zeta potentials at 251.6 nm, —34.6 mV, respectively. The lyophilized product of nattokinase immunoliposomes exhibited good appearance and satisfactory redispersibility, with its loss on drying at 14.30% and critical relative humidity at 45.66%. CONCLUSION: Nattokinase immunoliposomes and its lyophilized product have been prepared successfully.
