Content Determination of Main Compontents in Haloperidol Tablets by HPLC
- VernacularTitle:HPLC法测定氟哌啶醇片中主药的含量
- Author:
Min LIU
;
Yulan LI
;
Tiejie WANG
;
Jun LI
- Publication Type:Journal Article
- Keywords:
Haloperidol tablets;
HPLC;
Content determination
- From:
China Pharmacy
1991;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To develop an HPLC method for determination of the content of the main compontents in haloperidol tablets. METHODS: The samples were determined on Diamonsil C18 column at a column temperature of 35 ℃. The mobile phase consisted of 0.1 mol?L-1 K2HPO4 (pH 3.0)-methanol (45∶55) at a flow rate of 1.0 mL?min-1. The UV detection wavelength was 248nm and the sample size was 20 ?L. RESULTS: The linear range for haloperidol was 0.01～1 mg?mL-1 (r=0.999 9) and its average recovery was 97.6% (RSD=1.1%). CONCLUSIONS: The method was simple, rapid, accurate and specific, and suitable for the quality control of this preparation.
