Preparation of Triptolide-loaded Microspheres and Its Release Profile in Vitro and in Vivo
- VernacularTitle:雷公藤内酯醇缓释微球的制备及体内外释放规律研究
- Author:
Hua JIANG
;
Suodi ZHAI
- Publication Type:Journal Article
- Keywords:
Triptolide;
Sustained release microspheres;
Preparation;
Release profile
- From:
China Pharmacy
1991;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To prepare triptolide-loaded sustained release microspheres and investigate its release profile in vivo and in vitro.METHODS:Triptolide-loaded sustained release microspheres were prepared by solvent evaporation method.A motionless method was used to investigate the process of release in vitro.The in vivo release process was investigated by pharmacokinetic experiment in rats.RESULTS:The microspheres were round and smooth examined by optical microscope.The size of triptolide loaded microspheres was(38.2?1.7) ?m and the encapsulation efficiency of triptolide loaded microspheres was(74.7?3.2)%.A constant in vitro release of triptolide-loaded microspheres was noted.The pharmacokinetic parameters of microspheres in vivo were as follows:Cmax was(114.7?31.90) ng?mL-1;tmax was(8.32?4.43) h;AUC was(1 774 282?1 046 152) ng?h?mL-1 and MRT was(596?165) h.In addition,the in vivo-in vitro correlation was good,r=0.955 3(P
