Protective effect of naoyikang-containing serum on cultured hippocampus neuron injury induced by D-galactose
- VernacularTitle:脑益康对D-半乳糖损伤的海马神经元的保护作用
- Author:
Yan ZHU
;
Ailing ZHOU
;
Yae HU
;
Jiahui MAO
;
Haiyan SHI
- Publication Type:Journal Article
- Keywords:
Naoyikang;
Hippocampus;
Neurons;
Monoamine oxidase;
bax mRNA;
bcl-xl mRNA
- From:
Chinese Journal of Pathophysiology
1986;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To observe the protective effect of naoyikang-containing serum on cultured hippocampus neuron injury induced by D-galactose(D-gal).METHODS: Naoyikang-containing serum was prepared in rats administered with aqueous extract of naoyikang(6.84 g?kg-1?d-1).MTT,MAO-B and ATPase assay were used to measure the viability of hippocampus neurons.RESULTS: D-gal at concentration of 100 ?mol/L caused significant decrease in the viability of hippocampus neurons 24 h after the treatment.Naoyikang-containing serum increased the viability,ATPase activity and the expression of bcl-xl mRNA,decreased the MAO-B activity and the expression of bax mRNA in D-gal injured hippocampus neurons.CONCLUSION: Naoyikang-containing serum prevents hippocampus neurons from D-gal induced cytotoxicity.
