Effect of puerarin on myocardial injury in KKA~y diabetic mice
- VernacularTitle:KKA~y糖尿病鼠心肌损伤及葛根素的干预作用
- Author:
Jinli LOU
;
Qian WANG
;
Ran HAO
;
Qifu HUANG
- Publication Type:Journal Article
- Keywords:
Diabetes mellitus,non-insulin-dependent;
Myocardial injury;
Apoptosis;
Mitochondrial apoptotic pathway;
Puerarin
- From:
Chinese Journal of Pathophysiology
1986;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To observe the effect of puerarin on myocardial injury according to the time of occurrence of myocardial injury in the development of type 2 diabetic mice.METHODS: The serum levels of glucose(GLU),triglyceride(TG),total cholesterin(TC),low density lipoprotein-cholesterol(LDL-C) and high density lipoprotein-cholesterol(HDL-C) in 17-week,20-week,24-week,28-week KKAy mice were detected by automatic biochemical methods.The apoptotic percentage of cardiomyocytes was examined by flow cytometry.The expressions of bax and bcl-2 mRNA in cardiomyocytes were detected by RT-PCR.Caspase-3 expression in cardiomyocytes was determined by immunohistochemical staining.RESULTS: Compared to normal control mice,not only GLU level increased,but also the levels of TG,TC,LDL-C,HDL-C in 20-week,24-week and 28-week KKAy mice increased apparently(P
