WTX:the Wilms tumor suppressor gene located on the sex-determining X chromosome
- VernacularTitle:WTX基因:第一个位于X染色体上的肾母细胞瘤抑癌基因
- Author:
Shuishan ZHU
;
Hui GONG
;
Hongxing GUO
;
Jixiang ZHANG
- Publication Type:Journal Article
- Keywords:
Wilms tumor;
WT1;
WTX;
?-catenin
- From:
Chinese Journal of Pathophysiology
1986;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Wilms tumor(WT) is one of the most common renal malignancies in children.Although several genetic loci such as the WT1,WT2,p53 and ?-catenin genes have been considered to be associated with WT,the causes of the tumor are still unknown.Recently the US researchers have identified a new tumor suppressor gene that is mutated in WT.The biological function of the protein encoded by WTX is yet unknown,however,the gene's location in the X chromosome is of particular interest.This review highlights the current study of the gene mutated in Wilms tumor.
