Protective role and mechanism of peroxysome proliferator activated receptor-? in injury of cultured rat cortical neurons induced by hypoxia/ reoxygenation
- VernacularTitle:PPAR-?激动剂减轻缺氧性大鼠神经细胞损伤的作用机制
- Author:
Jingyuan ZHANG
;
Yanqiao ZHANG
;
Yina ZHANG
;
Lichun PEI
;
Changqing XU
;
Wei YANG
- Publication Type:Journal Article
- Keywords:
Rats;
Hypoxia;
Neurons;
Cyclooxygenase-2;
Peroxysome proliferator-activated receptor ?
- From:
Chinese Journal of Pathophysiology
1986;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To observe the role of peroxysome proliferator activated receptor-?(PPAR-?) and the relationship of cyclooxygenase-2(COX-2) and PPAR-? in injury of cultured rat cortical neurons induced by hypoxia/reoxygenation.METHODS: Primary rat cortical neurons were cultured.Experiments include control group,hypoxia/ reoxygenation group and hypoxia/ reoxygenation with PPAR-? agonist group.Cell viability was surveyed by MTT assay.COX-2 protein expression was measured by Western blotting.RESULTS: Neuron viability raised dramatically in hypoxia/reoxygenation with PPAR-? agonist group,compared with hypoxia/reoxygenation group(P
