Inhibitory Effect of Tea Polyphenols in Combination with Anti-tumor Drugs on Cell Proliferation of the Multiresistant HNE-1 Cell Line
- VernacularTitle:茶多酚与抗肿瘤药物联合作用对人鼻咽癌耐药细胞株HNE-1增殖抑制的影响
- Author:
Chi WANG
- Publication Type:Journal Article
- Keywords:
Tea polyphenols;
Anti-tumor drugs;
HNE-1(200) cell line of nasopharyngeal carcinoma;
Inhibition on cell proliferation
- From:
China Pharmacy
1991;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE: To study the joint action of tea polyphenols and common anti-tumor drugs(vincristine,pingyangmycin,5-Fu,cisplatin) in inhibiting cell proliferation of the multiresistant HNE-1(200) cell line in patients with nasopharyngeal carcinoma after radiographic exposure.METHODS: The low toxic dosage of tea polyphenols and 4 kinds of anti-tumor drugs were optimized by MTT method.Then the inhibition ratio of multiresistant HNE-1(200) cell line treated by tea polyphenols and anti-tumor drugs waere detected.RESULTS: The low toxic dosage of tea polyphenols was 0.50 mg?mL-1.When the anti-tumor drugs were used in combination with tea polyphenols(0.50 mg?mL-1) as compared without,the inhibition ratio on HNE-1(200) cell line was increased by 100%～300%.CONCLUSIONS: Addition of tea polyphenols to anti-tumor drugs showed remarkable inhibitory effect on cell proliferation of HNE-1(200) cell line in patients with nasopharyngeal carcinoma,suggesting the reverse effect of tea polyphenols on resistant HNE-1(200) cell line.
