Determination of Rosiglitazone in Compound Rosiglitazone Metformin Tablet by HPLC
- VernacularTitle:HPLC法测定复方罗格列酮盐酸二甲双胍片中罗格列酮的含量
- Author:
Guojun WANG
- Publication Type:Journal Article
- Keywords:
HPLC;
Compound rosiglitazone metformin tablet;
Rosiglitazone;
Contents
- From:
China Pharmacy
1991;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE: To develop an HPLC method for the determination of rosiglitazone in compound rosiglitazone metformin tablet.METHODS: HPLC was performed on a Phenomenex Ods3-C18 column using 0.38% ammonium acetate-acetonitrile(50∶50) as the mobile phase at a flow rate of 1.0 mL?min-1.The detection wavelength was set at 247 nm and the sample size was 20 ?L.RESULTS: The standard curve of rosiglitazone was linear in the range of 20.40～183.60 ?g?mL-1(r=0.999 9);The average recovery was 99.5%,RSD=0.82%(n=5).CONCLUSIONS: The method is simple and accurate,and suitable for the determination of rosiglitazone in compound rosiglitazone metformin tablet.
