Optimization of the Extraction Process of Renzhi Anti-cough Granules by Orthogonal Experiment
- VernacularTitle:正交试验优选仁志止咳颗粒的提取工艺
- Author:
Zhizhen ZHAO
- Publication Type:Journal Article
- Keywords:
Renchi anti-cough granules;
extraction process;
Orthogonal design
- From:
China Pharmacy
2007;0(36):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To optimize the extraction process for Renzhi anti-cough granules.METHODS:The preparation process was optimized by orthogonal experiment design L9(33) with the amount of solvent,extraction times and concentration of alcohol as factors and with yield of paste,the latency for the cough of mice and the cough times as indexes. RESULTS:The optimum extraction process was as follows:Adding 5 times of solvent for extraction twice,and the extractum obtained was dissolved with 60% alcohol and stayed still overnight,then the supernatant was taken for filtration with ethanol-extract filtrate recovered under reduced pressure until paste was obtained,then 4 times of thoroughly mixed mixture of sugar-starch (3∶2;the starch was dried at 105 ℃ for 1 hour in advance) was added to prepare soft material,after sieving,drying and granulation,porous yellowish granules were obtained.CONCLUSION: The method can help reduce the dosage needed while enhancing drug efficacy and it is applicable for the preparation of Renzhi anti-cough granules.
