Quality Standard of Jiuweiniuhuang Pills,a Tibetan Patent Medicine
- VernacularTitle:藏成药九味牛黄丸质量标准研究
- Author:
Farong YUAN
;
Lianping DU
;
Chengfang HAN
;
Sangmao QIENING
- Publication Type:Journal Article
- Keywords:
Jiuweiniuhuang pills;
Aristolochic acid A;
Costunolide;
Dehydrocostuslactone;
RP-HPLC
- From:
China Pharmacy
2007;0(36):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To establish a method for the quality control of Jiuweiniuhuang pills.METHODS:TLC was applied for the quantitative identification of Bostaurus domesticus,Carthamus tinctorius and Aucklandia lappa in this prescription as well as the testing of the limit of Aristolochic acid A. RP-HPLC method was established for determination of Costunolide and Dehydrocostuslactone.RESULTS: The TLC spots were clear,well-separated,specific and free from interference of negative sample. The content of Aristolochic acid A which stood at less than 2.5 ?g?6 g-1 was up to the standard.Costunolide showed a linear relationship at the concentration range of 0.26～1.3 ?g with an average recovery of 99.8% (RSD=1.1%,n=6); and Dehydrocostuslactone showed a linear relationship at the concentration range of 0.258～1.29 ?g with an average recovery of 98.2%(RSD=1.7%,n=6).CONCLUSION: The method is suitable for the quality control of Jiuweiniuhuang pills.
