Effects of Various Microsomal Drug-metabolizing Enzymes on Specific Glucuronidation of Baicalein in Rats' Liver and Intestine
- VernacularTitle:大鼠肝肠不同微粒体药物代谢酶对黄芩素葡糖醛酸酸化代谢物的影响研究
- Author:
Xiaobin GUAN
- Publication Type:Journal Article
- Keywords:
Baicalein;
Microsome;
Metabolism;
Rat
- From:
China Pharmacy
2007;0(36):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the effect of rat liver and intestine on the metabolism of Baicalein.METHODS: The microsomal drug-metabolizing enzyme incubation method was employed,and the contents of bacicalein and its glucuronidation metabolite at different incubation time were determiend by HPLC. The effects of various microsomes on the glucuronidation rates of Baicalein were studied.RESULTS:Different microsomal drug-metabolizing enzymes contributed to the metabolism of Baicalein in time-and concentration-dependent manner,with Jejunum microsome the strongest while the colon microsome the weakest in efficacy.CONCLUSION:Baicalein had a strong metabolism in liver and intestine especially in the intestine.
