Pathology of Renal Transplantation.
- Author:
Moon Hyang PARK
1
Author Information
1. Department of Pathology, College of Medicine, Hanyang University, Korea. parkmh@hanyang.ac.kr
- Publication Type:Review
- Keywords:
Kidney transplantation;
Graft rejection;
Pathology
- MeSH:
Allografts;
Biopsy;
Diagnosis;
Drug-Related Side Effects and Adverse Reactions;
Graft Rejection;
Kidney Transplantation*;
Necrosis;
Nephritis, Interstitial;
Pathology*;
Perfusion;
Transplants
- From:Hanyang Medical Reviews
2006;26(3):32-47
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Even with improved immunosuppressive therapies, graft rejection remains the major cause of failure. Renal biopsy is the most sensitive tool and gold standard for the diagnosis of rejection and other causes of graft dysfunction. Because of the large number of conditions that can affect the allograft, sometimes in combination, renal transplantation pathology is one of the most challenging areas for the renal pathologist. The major causes of allograft dysfunction include rejection, postoperative acute tubular necrosis, perfusion injury, drug toxicity, obstruction, major vascular occlusion, infection, allergic interstitial nephritis, recurrent or de novo glomerular disease, and post-transplant lymphoproliferative disease. The criteria for grading rejection by the Banff 97 schema and the new concept of acute antibody-mediated rejection are introduced.
