Effects of SDZ on LOVO Cell Line and the Expression of E-Cadherin and N-Cadherin
- VernacularTitle:SDZ对人大肠癌LOVO细胞系的作用及其对E-、N-Cadherin表达的影响
- Author:
Di WU
;
Jinxue TONG
- Publication Type:Journal Article
- Keywords:
SDZ;
Traditional Chinese medicine;
Human colorectal cancer cell line LOVO;
RT-PCR
- From:
China Pharmacy
2007;0(36):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the effects of SDZ on LOVO cell line and the expression of E-Cadherin and N-Cadherin. METHODS: The apoptosis of SDZ on growth of LOVO cells was observed under electron microscope and inverted microscope. The expression of E-Cadherin and N-Cadherin treated by SDZ were detected by RT-PCR. RESULTS: SDZ promoted the apoptosis of LOVO cell lines and increased the expression of E-Cadherin,however,it did no effect on the expression of N-Cadherin. CONCLUSION: SDZ can enhance the intercellular adhesiveness and degrade the capability of infiltration and metastasis of tumor cells.
