Clinical Strategies to Develop Transplantation Tolerance.
- Author:
Jong Soo LEE
1
;
Byungsuk KWON
;
Hong Rae CHO
Author Information
1. Department of Internal Medicine, Ulsan University Hospital, College of Medicine, University of Ulsan, Korea.
- Publication Type:Review
- Keywords:
Transplantation tolerance;
Mixed hematopoietic chimerism;
Costimulatory blockade;
T cell depletion;
Regulatory T cells
- MeSH:
Allografts;
Chimerism;
Graft Survival;
Immune Tolerance;
Immunosuppressive Agents;
T-Lymphocytes, Regulatory;
Transplantation Tolerance*
- From:Hanyang Medical Reviews
2006;26(3):70-76
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
The development of immunosuprressants has had a significant influence on inhibition of acute allograft rejection. However, long-term graft survival has not been achieved by immunosuppressants, probably because of their nonspecific suppression of T cell activity and nonimmune side effects. The ideal way to overcome the limitations of current immunosuppressants is to induce allograft-specific immune tolerance. Transplant immunologists are exerting their efforts in achieving transplantation tolerance using four different approaches; costimulatory blockade, mixed hematopoietic chimerism, T cell depletion, and regulation by regulatory T cells. It is expected that transplantation tolerance will soon be established as a standard immunosuppressive regimen with little side effects in preventing and reversing allograft rejection.
