Clinical Efficacy of Cefepime in Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease(AECOPD) Complicated with Respiratory Failure
- VernacularTitle:头孢吡肟治疗慢性阻塞性肺疾病急性加重期并呼吸衰竭的疗效观察
- Author:
Sijing LU
;
Yu LIU
;
Zhong LIU
;
Xue JIAO
- Publication Type:Journal Article
- Keywords:
Cefepime;
Acute exacerbation of chronic obstructive pulmonary diseases (AECOPD);
Respiratory failure
- From:
China Pharmacy
2007;0(35):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To observe the efficacy and safety of domestic cefepime in the treatment of patients with acute exacerbation of chronic obstructive pulmonary diseases (AECOPD) complicated with respiratory failure. METHODS:A total of ninety-six patients with AECOPD complicated with respiratory failure were randomly assigned to receive cefepime 2.0 g bid iv gtt (Group A,n=48) or cefoperazone/sulbactam (Group B,n=48) at a dose of 2.0 g bid iv gtt for 7～14 day. RESULTS:The effective rate was 82% for Group A versus 62% for Group B(P0.05). CONCLUSION:The efficacy of cefepime is higher than that of cefoperazone/sulbactam in the treatment of patients with AECOPD complicated with respiratory failure,but both had good safety.
