Sompatible Stability of Cefoperazone Sodium/Sulbactam Sodium for Injection Mixing with Doxofylline for Injection
- VernacularTitle:注射用头孢哌酮钠/舒巴坦钠与多索茶碱的配伍稳定性考察
- Author:
Bo ZHANG
;
Xianghui LI
- Publication Type:Journal Article
- Keywords:
Cefoperazone sodium/ sulbactum sodium;
Doxofylline;
Stability;
Dual ultraviolet wavelength spectrophotometry;
Mixing
- From:
China Pharmacy
2007;0(35):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study the compatible stability of doxofylline for injection with cefoperazone sodium/sulbactam sodium for Injection. METHODS:The contents of 2 constituents in the mixed solution stored at (25?1)℃ within 6 hours were determined by dual ultraviolet wavelength spectrophotometry,and the appearance and pH value of the mixture were compared with those before mixing. RESULTS:There was no significant change in the content of doxofylline after mixing,while the contents of cefoperazone sodium and sulbactam sodium showed a slight reduction. No significant change was noted for other indexes. CONCLUSION:Doxofylline injection is compatible with cefoperazone sodium and sulbactam sodium for injection in 0.9% sodium chloride injection at 25℃ within 4 hours' mixing.
