Effect of sodium ferulate on heat shock protein 27 phosphorylation in vascular smooth muscle cells
- VernacularTitle:阿魏酸钠对血管平滑肌细胞热休克蛋白27磷酸化的影响
- Author:
Liangdi XIE
;
Haifeng CHEN
;
Changsheng XU
- Publication Type:Journal Article
- Keywords:
Ferula;
Heat shock proteins 27;
Angiotensin Ⅱ;
Platelet derived growth factor;
Muscle,smooth,vascular
- From:
Chinese Journal of Pathophysiology
2000;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To investigate the effect of sodium ferulate on phosphorylation of heat shock protein 27(HSP27) in vascular smooth muscle cells(VSMCs) induced by angiotensin Ⅱ(AngⅡ) and platelet derived growth factor-BB(PDGF-BB).METHODS: Cultured VSMCs derived from rat thoracic aorta were used.The activity of HSP27 was evaluated by Western blotting with specific phospho-HSP27 antibody.RESULTS: The phosphorylation of HSP27 in response to AngⅡ and PDGF-BB was suppressed by sodium ferulate in a dose-dependent manner,with maximal inhibition rates of 39.0%(P
