Effect of erythromycin on transforming growth factor-?_1 and ?-glutamylcysteine synthetase in lung of smoking rats
- VernacularTitle:红霉素对吸烟大鼠肺内TGF-?_1和?-GCS表达的影响
- Author:
Jianying XU
;
Yanrong GUO
;
Meiping XUE
- Publication Type:Journal Article
- Keywords:
Pulmonary disease,chronic obstructive;
Erythromycin;
Transforming growth factor beta;
?-Glutamylcysteine synthetase
- From:
Chinese Journal of Pathophysiology
2000;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To investigate the effect of erythromycin on the level of transforming growth factor-?1(TGF-?1) and ?-glutaglutamylcysteine synthetase(?-GCS) in smoking rats,and to explore the antioxidate therapeutic role of erythromycin in chronic obstructive pulmonary disease.METHODS: Wistar rats were exposed to cigarettes smoking to establish the model.After passive smoking for 4 weeks,erythromycin intragastric intervention was administered continuously for 8 weeks.The expiratory airway resistance and lung compliance were assessed and the expression levels of TGF-?1 and ?-GCS proteins(and the mRNA) in airway endothelial cells and alveolar macrophages were observed respectively by immunohistochemical,immunocytochemical and(in situ) hybridization.RESULTS: The expiratory airway resistance was increased and the lung compliance was degraded significantly in smoking group and erythromycin group,compared to control group.In erythromycin group,the airway resistance was lower and the lung compliance was higher than that in smoking group(P
