Preparation and Pharmaceutic Property of Core-shell Nanocapsules Containing Nicardipine Hydrochloride
- VernacularTitle:盐酸尼卡地平核壳型纳米囊的制备及其药剂学性质研究
- Author:
Xiangrong ZHOU
;
Baiwang SUN
;
Huina CHEN
- Publication Type:Journal Article
- Keywords:
Core-shell nanocapsules;
Layer-by-layer electrostatic self-assembly;
Nicardipine hydrochloride
- From:
China Pharmacy
2007;0(34):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To prepare core-shell nanocapsules loading nicardipine hydrochloride and to investigate its pharmaceutical characteristics. METHODS: Core-shell nanocapsules were prepared using layer-by-layer electrostatic self-assembly technique. The indexes including the shape and particle size and the loaded drug amount of the nanocapsules were evaluated, and its accumulative release rates in artificial gastric juice and intestinal juice were computed and compared with those of its crude drug. RESULTS: The results showed that the nanocapsules were spherical with a mean particle size of 200 nm and a maximum loaded drug amount of 2.512%. The drug release rate within 12 h reached 18.64% in artificial gastric juice and 70% in artificial intestinal juice, whereas within 3 h the drug release rate of its crude drug in artificial intestinal juice reached 87%. CONCLUSIONS: The prepared core-shell nanocapsules containing nicardipine hydrochloride had a good pharmaceutical property.
