Preparation and Release of Compound Alendronate Sodium Sustained-release Tablet in Vitro
- VernacularTitle:复方阿仑膦酸钠缓释片的制备及体外释放度考察
- Author:
Mingli LONG
;
Jianguo ZENG
- Publication Type:Journal Article
- Keywords:
Alendronate sodium;
Sustained-release tablet;
Orthogonal design;
Release rate in vitro
- From:
China Pharmacy
2007;0(34):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To prepare compound alendronate sodium sustained-release tablet and to investigate its drug release profile in vitro. METHODS: Hydroxy propyl methylcellulose (HPMC), ethylcellulose (EC), and lactis anhydrous were used to prepare sustained-release tablets by wet granule compression technique with release rate in vitro as index. Orthogonal experiment was conducted to optimize the formula. The release rate of the tablets in vitro was investigated. RESULTS: The optimized formula was as follows: HPMC 80 mg, EC 20 mg, and lactis anhydrous 20 mg. 12 h drug release of the preparation was achieved, and the drug release behavior in vitro fitted Higuchi equation. CONCLUSION: The sustained-release tablet is reasonable in formula and satisfactory in slow release efficacy.
