Effect of Yupingfeng Extract on Bone Metabolism in Model Rats with Osteoporosis Induced by Cyclophosphamide
- VernacularTitle:玉屏风水提液对环磷酰胺致骨质疏松模型大鼠骨代谢的影响
- Author:
Jiantao LIN
;
Tie WU
- Publication Type:Journal Article
- Keywords:
Yupingfeng(YPF)extract;
Cyclophosphamide;
Ca;
P;
Mg;
Hydroxyproline;
Rat
- From:
China Pharmacy
2007;0(33):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study the effect of Yupingfeng(YPF)extract on Ca,P,Mg and hydroxyproline of bone in model rats with osteoporosis induced by cyclophosphamide(CP)and to discuss the preventive and therapeutic effect of YPF ext-ract on CP-induced osteoporosis.METHODS:A total of 40 rats were randomly divided into four groups:control group,CP group,YPF extract group,and calci?m carbonate + Vit D group.The rats were sacrificed at 15 days of experiment,and the levels of Mg,Ca,P and hydroxyproline of left femoral bone were determined.RESULTS:Compared with control group,levels of different index with CP group was significantly decreased;compared with CP group,levels of Ca,Mg,P and hydroxyproline of bone in rats treated with YPF extract were significantly increased.CONCLUSION:CP may induce decrease of levels of Ca,Mg,P and hydroxyproline of bone,however,on which YPF extract has preventive and therapeutic effect.
