RP-HPLC Analysis and Pharmacokinetics Study of Serum Carthamin in Mice
- VernacularTitle:小鼠血浆中红花红色苷的RP-HPLC法分析及其药动学研究
- Author:
Xiuying XU
;
Yimin ZHENG
;
Shanquan FU
;
Yumei HAN
;
Ali WANG
- Publication Type:Journal Article
- Keywords:
RP-HPLC;
Carthamin;
Pharmacokinetics;
Serum drug concentration
- From:
China Pharmacy
2007;0(33):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To establish an RP-HPLC analysis of Carthamin in mice and to study its pharmacokinetics.METHODS:The serum concentration of Carthamin was determined by RP-HPLC.The blood concentration-time curve was established and the main pharmacokinetic parameters were computed.RESULTS:The linear range of Carthamin was 0.558～55.8 ?g?L-1(r=0.999 2),with the lowest limit of detection at 0.005 ?g?L-1Carthamin in vivo assumed two-compartment model and rapid absorption.CONCLUSION:The proposed method is simple,sensitive and reproducible,and it met the standard for pharmacokinetic study.
