Domestic and Original Sodium Valproate Sustained-release Tablet in Releasing Rate in Vitro
- VernacularTitle:国产与原研丙戊酸钠缓释片的体外释放度考察
- Author:
Xiaolin ZHENG
- Publication Type:Journal Article
- Keywords:
Sodium valproate;
Sustained-release tabltes;
Release rate
- From:
China Pharmacy
2001;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE: To evaluate the releasing characteristics of domestic and original sodium valproate sustained-release tablet in vitro.METHODS: The drug releasing rates of the tablests were determined according to dissolution method Ⅱ of the Chinese Pharmacopoeia and potentiometry.The parameters of the releasing rate(T50,Td,and m) were obtained by the weibull disposition and excel.Analysis of variance of the parameters were statistically evaluated by q-test.RESULTS: There were significant differences between the domestic and original sodium valproate sustained-release tablets in T50 and Td(P0.05),nor in release parameters.CONCLUSIONS: There was no difference in accumulative releasing amount between domestic and original sodium valproate sustained-release tablets in study period,but the domestic tablets showed higher release velocity at the initial release period.The two tablets were both stable in technology,but different in quality.
