Anticoagulative and Antithrombotic Activity of Tongsai Ruanmai Tablets
- VernacularTitle:通塞软脉片抗凝血和抗血栓作用实验研究
- Author:
Yan WANG
- Publication Type:Journal Article
- Keywords:
Tongsai ruanmai tablets;
Anticoagulation;
Antithrombotic activity;
Empirical study
- From:
China Pharmacy
2007;0(33):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study the anticoagulative and antithrombotic activity of Tongsai ruanmai tablets.METHODS:The effects of Tongsai ruanmai tablets on coagulation time, prothrombin time(PT),the fibrinogen(Fbg) content and the dissolution rate of blood clot were observed. The antithrombotic effect of Tongsai ruanmai tablets was also studied by thrombogenesis dissolution test in vivo and in vitro in rats. RESULTS: At the dose of 0.5, 1.0 and 2.0 g?kg-1,Tongsai ruanmai tablets could significantly prolong the coagulation time and PT in rats, decrease the Fbg content, increase the dissolution rate of blood clots, prolong carotid artery thrombosis formation time, shorten the length of thrombosis of rats in vitro, lessen the wet weight and dry weight of thrombosis of rats.CONCLUSION:Tongsai ruanmai tablets possess anticoagulative and antithrombotic activity.
