Effect of Ibudilast on the quality of life of patients with steroid resistant allergic rhinitis:a randomized,double blind,controlled study
- VernacularTitle:异丁司特对类固醇抵抗型变应性鼻炎患者生活质量的影响
- Author:
Hong LUO
;
Xiaoling LIU
;
Zezhang TAO
;
Nengbing YAN
;
Guangzhen PAN
;
Yan JIANG
;
Ye YU
;
Jiangping LI
- Publication Type:Journal Article
- Keywords:
Rhinitis,Allergic,Perennial;
Hormones;
Drug Resistance;
Quality of Life;
Questionnaires
- From:
Chinese Archives of Otolaryngology-Head and Neck Surgery
2006;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To assess the effect of Ibudilast on the quality of life (QOL) of patients with steroid resistant allergic rhinitis.METHODS A randomized,double-blind,placebo-controlled study was carried out with Ibudilast in 66 patients with the steroid resistant allergic rhinitis.QOL was measured with Short-Form Health Survey (SF-36) questionnaire (Chinese version).Ibudilast (10rag twice daily,34 patients),placebo (32 patients) was given for 3 weeks. The SF-36 questionnaire was administered at the start of treatment and after 3 weeks of treatment.Sings and Symptom-medication scores were measured daily during the study.RESULTS There were no significant differences between the Ibudilast and placebo group in terms of sings and symptoms or QOL scores before study.After 3 weeks of treatment,symptoms scores were significantly decreased and QOL scores significantly improved in the Ibudilast group compared with those in placebo group (both P
