Assessment and Analysis of Quality Control for Therapeutic Drug Monitoring of Cyclosporine A and Tacrolimus
- VernacularTitle:环孢素A和他克莫司血药浓度监测的质控评价与分析
- Author:
Cheng XIE
;
Meiying QIAN
;
Liyan MIAO
- Publication Type:Journal Article
- Keywords:
Cyclosporine A;
Tacrolimus;
Therapeutic drug monitoring;
Quality control
- From:
China Pharmacy
2007;0(32):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To assess the stability of the quality control of FPIA for monitoring of CsA and MEIA for monitoring of FK506.METHODS:The quality control on the blood samples of patients receiving therapeutic drug monitoring of CsA and FK506 from June to August in 2007 were subjected to a continual assessment and analysis to investigate the stability and accuracy of the quality control.RESULTS:The mean recoveries of the low,middle and high concentrations of CsA and FK506 were 93.14%～97.65% and 97.70%～103.09% respectively,with RSD at 4.41%～5.37% and 10.44%～14.23% respectively,which accorded with the requirement for biological sample determination stated in the Chinese Pharmacopoeia.CONCLUSION:The methods of FPIA for monitoring of CsA and MEIA for monitoring of FK506 were accurate,and worth to be applied in clinical to guide individualized medication.
