Adverse Drug Reactions Induced by Antibiotics:Literature Analysis
- VernacularTitle:抗菌药物不良反应文献分析
- Author:
Mei GUAN
;
Yuxian CHEN
- Publication Type:Journal Article
- Keywords:
Adverse drug reaction;
Antibiotics;
Rational use
- From:
China Pharmacy
2007;0(32):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study the incidence,types,constitution ratio of adverse drug reactions(ADR)induced by antibiotics and the correlation factors of the ADR so as to promote rational drug use in our hospital.METHODS:The literature about antibiotics-induced ADR from Jan.1980 to May 2008 retrieved from CNKI,Wanfang Data and VIP full-text data base was analyzed quantitatively by dividing the literature into different categories:case study or typical case reports,clinical trial or observational reports,and regional ADR monitoring data base or hospital ADR analytical reports.RESULTS:There were 2 310 case studies or typical case reports and in which 3 794 ADR cases were reported,which manifested chiefly as allergic reaction(35.58%),nervous system reaction(17.82%)and disulfiram-like reaction(in 546 cases).928 papers were literature about clinical trial or observational reports and in which 9 434 ADR cases were reported and the average ADR incidence was 9.14%,with anti-tuberculosis drugs showing the highest proportion(25.57%),followed by nitromidazole(24.29%)and carbapenem antibiotics(23.52%);and the ADR manifested chiefly as gastrointestinal tract reaction and allergic reaction,and there were ADR cases manifested as pathoglycemia induced by quinolones.There were 300 papers were literature about regional ADR monitoring data base or hospital ADR analytical reports,in which almost all the major variety of antibiotics were involved,leading the list in terms of ADR cases were quinolones,penicillins and cephalosporins.CONCLUSION:Great importance should be attached to the rational use of antibiotics so as to avoid or reduce ADR incidence and ensure safe and effective use of antibiotics in patients.
