Anti-neoplastic Effect of Xuezhikang in vitro
- VernacularTitle:血脂康胶囊的体外抗肿瘤作用
- Author:
Zhong YANG
;
Junxian ZHAO
;
Yingge ZHANG
- Publication Type:Journal Article
- Keywords:
Xuezhikang (Regulate blood-fat) Capsule;
Lovastatin;
Cancer;
Enhancement
- From:
Journal of Traditional Chinese Medicine
1992;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the anti-neoplastic effect of Xuezhikang (Regulate blood-fat) Capsule in vitro and its influence on the chemotherapeutic drug 5 Fluorouracil (5-Fu).Methods Using MTT method to measure the inhibition rate of Xuezhikang Capsule used simply,5-Fu used simply and Xuezhikang Capsule with 5-Fu together on HepG2,MCF-7 and HL-60 cells.Results The inhibitory action of Xuezhikang Capsule(2.56,0.64,0.16,0.04,0.01 mg/ml) on HepG2,MCF-7 and HL-60 cells was dose-dependent and the IC50 was 14.057,19.859 and 27.771mg/ml respectively.The inhibition ratio of five different doses of Xuezhikang Capsule(0.64,0.16,0.04,0.01,0.0025 mg/ml) with 5-Fu (0.24mg/ml) together all remarkably higher than that of 5-Fu used simply.Conclusion Xuezhikang Capsule has a significant anti-cancer effect in vitro and can enhance remarkably the anti-neoplastic effect of 5-Fu.
