Investigation of the correlation between a group of metastasis-associated proteins and metastatic potency in breast carcinoma
- VernacularTitle:转移相关蛋白与乳腺癌转移潜能的相关性分析
- Author:
Aiju FANG
;
Yongsheng GAO
;
Shengmei LI
;
Wenjun LIU
;
Bin MENG
- Publication Type:Journal Article
- Keywords:
Breast Neoplasms;
Neoplasms Metastasis;
Tissue Microarray;
Factor Analysis
- From:
Chinese Journal of General Surgery
2000;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression and the significance of a group of metastasis-associated proteins in invasive ductal breast carcinoma(IDC).Methods Tissue microarray containing 247 IDC specimens was constructed.The expressions of ?-B crystallin,CD44v6,MMP-2 and TIMP-2 were detected by immunohistochemistry,and the relation between the expression of these proteins and the clinicopathologic character was analyzed.Results(1) The expression rates of ?-B crystallin,CD44v6,MMP-2 and TIMP-2 in IDC were 70.0%,61.5%,57.5% and 57.1% respectively,and significantly higher than those of normal breast tissues(P
