Optimization of the Formulation and Technology of Lovastatin Capsule by Orthogonal Test
- VernacularTitle:正交试验优选洛伐他汀胶囊处方工艺
- Author:
Huifang LIU
- Publication Type:Journal Article
- Keywords:
Orthogonal design;
Lovastatin;
Polyvinylpyrrolidone;
Formulation and technology
- From:
China Pharmacy
2007;0(31):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE: To optimize the preparation technology for the lovastatin capsules.METHODS: Orthogonal test was used to optimize the conditions for the technology of preparation meanwhile a dissolution test was conducted.RESULTS: According to the results of the single factor analysis and orthogonal test,the optimal condition for the lovastatin capsules were as follows: agglomerant: 10%PVP;disintegrator: CMS-Na was used by combining exterior and interior addition(2∶1);stuffing capsule by granules;wetting agent of twice granulating: 75% alcohol.The 30 min dissolution rate of the capsules prepared in the optimized technology reached above 92%.CONCLUSION: This preparation is stable in technology,reproducible and with high dissolution rate.
