Effect of Glycyrrhizin on Eotaxin Expression in Lung Tissue in Asthmatic Model Mice
- VernacularTitle:甘草酸对哮喘小鼠肺组织Eotaxin表达的影响
- Author:
Xiaohua LV
;
Tie WU
;
Dongyun QIN
- Publication Type:Journal Article
- Keywords:
Glycyrrhizin;
Bronchial asthma;
Mice;
Eotaxin
- From:
China Pharmacy
2007;0(31):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE: To explore the effect of glycyrrhizin on eotaxin expression in lung tissue from asthmatic model mice and the mechanism for glycyrrhizin to treat bronchial asthma.METHODS: The mice were randomized to asthma model group,prednisone-treated group and glycyrrhizin-treated group and normal control group.Egg protein asthma mouse model was established before being giving the corresponding drugs.Then the mice were sacrificed after 4 weeks for the counting of eosinophils in bronchoalveolar lavage fluid(BALF) and detection of Eotaxin expression in lung tissues by immunohistochemistry,with the results compared with normal control group.RESULTS: In glycyrrhizin-treated group compared with model group,the counting of eosinophils in BALF were decreased(P
