Effects of Enalapril and Irbesartan on the Expression of Related Plasma Molecule-marker
- VernacularTitle:依那普利和厄贝沙坦对相关血浆分子标记物表达的影响研究
- Author:
Dazhi WANG
;
Zhiqiang WANG
;
Shuyu ZHANG
- Publication Type:Journal Article
- Keywords:
Hypertension;
Irbesartan;
Enalapril;
sICAM-1;
PAI-1
- From:
China Pharmacy
2007;0(31):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE: To investigate the effects of irbesartan and enalapril on the blood pressure and the expression of related plasma molecule-marker in SHR rats.METHODS: Forty SHR were randomly divided into irbesartan group(SHR-I),enalapril group(SHR-E),irbesartan-enalapril group(SHR-IE) and blank control group(SHR-C).Another ten WKY rats were assigned to normal group(WKY).The blood pressure and activities of sICAM-1 and PAI-1 were measured after 16-week's intragastric administration with corresponding drugs,and then the results were compared with those before experiment.RESULTS: As compared before treatment,there were significant differences in blood pressure in all drug-treated groups after treatment(P
