Preparation and in Vitro Drug Release of Ganciclovir Lung-targeted Microcapsules
- VernacularTitle:更昔洛韦肺部靶向微囊的制备及体外释放度测定
- Author:
Rong DING
- Publication Type:Journal Article
- Keywords:
Ganciclovir;
Lung-targeted microcapsule;
Solvent evaporation method;
Release rate in vitro
- From:
China Pharmacy
2007;0(31):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE: To prepare and establish a release rate method for the determination of ganciclovir lung-targeted microcapsules.METHODS: The microcapsules were prepared by compound emulsion-dispersion solvent evaporation method.The in vitro drug release amount and release rate of the microcapsules were detected by UV spectrophotometry.RESULTS: The microcapsules were regular in shape with an average particle size of 13.87 ?m.The linear range of ganciclovir was 2～20 ?g?mL-1(r=0.999 9) and its average recovery was 99.96%(RSD=1.68%).The entrapment efficiency of the microcapsules was 63.85% and the drug release amount in vitro reached 40% in 24 hours.CONCLUSIONS: The microcapsules show significant sustained release character.
