L1210 Cell Apoptosis Induced by Curcumenol
- VernacularTitle:莪术醇诱导白血病L1210细胞凋亡作用研究
- Author:
Hai LIN
;
Xiaohui LI
- Publication Type:Journal Article
- Keywords:
Curcumenol;
Liposome;
L1210 cell;
Apoptosis
- From:
China Pharmacy
2007;0(30):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE: To investigate the effect and mechanism of Curcumenol against leukemia and to provide theoretical basis for the development and utilization of Curcumenol.METHODS:Curcumenol liposomes were prepared by mechanical dispersion method and ultrasonic method.MTT method was used to detect the inhibitory effects of Curcumenol and other drug on L1210 proliferation in mice with Lymphocytic leukemia.The apoptosis of L1210 cells induced by Curcumenol was observed under confocal microscope by trypan blue exclusion test and Hoechst 33258/PI double staining.RESULTS: Curcumenol significantly inhibited the proliferation of L1210 cells and induced apoptosis of L1210 cells.CONCLUSION: The anti-tumor effect of Curcumenol is possibly achieved by inducing the apoptosis of L1210 cells.
