Medico-legal evaluation followed muscular contusion based on the biochemical changes in SD rats' serum
- VernacularTitle:SD大鼠肢体挫伤后血清生化指标变化及其法医学意义
- Author:
Rongjun YU
;
Jun FAN
;
Senjie HU
- Publication Type:Journal Article
- Keywords:
Forensic pathology;
Contusion;
Biochemical indicator;
Myocardial damage
- From:
Chinese Journal of Forensic Medicine
2002;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the variations of biochemical indicators in serum followed the different contusion on soft tissues and also analyze their significance in forensic practice.Methods The SD rats were selected as experimental animal as well as were randomly divided into four groups: sham control,mild,medium and strong force depending on the height of strike falling in anesthesia state.Sacrificed the rats at the same time point and harvested the blood.Serumal creatine kinase(CK),isoenzyme of creatine kinase(CK-MB),lactate dehydrogenase(LDH),creatinine(Cr),urea nitrogen(UN) ?-hydroxybutyrate dehydrogenase(HBDH) and aspartic acid transferase(AST) were tested.The data were analyzed quantitatively with SPSS 12.0.Results The AST,CK,CK-Mb,HBDH,UN and Cr all increased accompanied with higher scale of strike.The statistics showed that a dramatically difference existed between the overall traumatic groups(including to the mild,medium and strong) and the control.The AST,CK and CK-MB showed significant differences in 3 experimental groups.Meanwhile,the perimeter of the traumatic limbs was a good marker for the power of the strike.Conclusion The contusion not only appeared in the local areas but also cause the myocardial damage in the period of early trauma.
