Meta-analysis of Telmisartan vs Losartan in the Treatment of Hypertension
- VernacularTitle:替米沙坦和氯沙坦治疗高血压的Meta分析
- Author:
Junfeng ZHU
;
Jincong ZHENG
- Publication Type:Journal Article
- Keywords:
Telmisartan;
Hypertension;
Efficacy;
Safety;
Meta-analysis
- From:
China Pharmacy
2007;0(29):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To evaluate the efficacy and safety of telmisartan in the treatment of hypertension.METHODS:The efficacy and safety of telmisartan versus losartan in treating hypertension reported in 5 studies were comprehensively evaluated with the meta-analysis in homogeneity test and combined test.RESULTS:Of the five randomized controlled trials(RCT) in which 771 patients who met the inclusion criteria were included,two studies were of high methodological quality according to Jadad scale.Meta analysis indicated that there was statistical significance between telmisartan and losartan in effectiveness(OR=1.55,95% confidence interval(1.12,2.16),P0.05).CONCLUSION:The effectiveness of telmisartan in the treatment of hypertension is significantly higher than that of losartan;however,there is no signficant differce in safety between the two drugs.
