Effect of Propofol on Apoptosis in Lung Tissue of Rats with Oleic Acid-induced Acute Lung Injury
- VernacularTitle:异丙酚对油酸性急性肺损伤模型大鼠肺组织细胞凋亡的影响
- Author:
Yanhong SHEN
- Publication Type:Journal Article
- Keywords:
Propofol;
Acute lung injury;
Rat;
Apoptosis;
Oleic acid
- From:
China Pharmacy
1991;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE: To investigate the effect of propofol on apoptosis in lung tissue of oleic acid-induced acute lung injury(ALI) rats.METHODS: Forty male SD rats were randomly divided into normal control group,ALI group,low,medium and high-dose(4,8,16 mg?kg-1?h-1) propofol groups.Except for the normal control group,the other 4 groups were infused with oleic acid through jugular vein followed by the infusing of the corresponding drugs for 4 h.Then the rats were sacrificed by exsanguination.Lung tissue was immediately sampled for observation of the pathologic change under light microscope and detection of apoptosis and the expression of Fas/FasL,Bax/Bcl-2 in lung tissue by FCM.RESULTS: In ALI group compared with the normal control group,the apoptosis rates in lung tissue cells was markedly increased(P
