Effect of astragalus polysaccharides on cholesterol efflux in THP-1 macrophage-derived foam cells
- VernacularTitle:黄芪多糖对THP-1巨噬细胞源性泡沫细胞胆固醇流出的影响
- Author:
Zhihong YANG
;
Wei GONG
;
Fengling CHEN
;
Wenbai ZHOU
;
Shuo ZHANG
;
Lianxi LI
;
Wenchang LIANG
;
Yehong YANG
;
Renming HU
- Publication Type:Journal Article
- Keywords:
Astragalus polysaccharide;
Macrophages;
Cholesterol;
ATP binding cassette transporter
- From:
Chinese Journal of Pathophysiology
2000;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM:To study the effect of astragalus polysaccharides(Aps)on cholesterol efflux in THP-1 macrophage-derived foam cells.METHODS:After exposed to Aps at different doses,cholesterol efflux and ABCA1 protein levels in cultured THP-1 macrophage-derived foam cells were determined by a ? counter and flow cytometry,respectively.RESULTS:Aps increased cholesterol efflux in THP-1 macrophage-derived foam cells with dose dependent pattern and resulted in an increase in the expression of ABCA1 protein in THP-1 macrophage-derived foam cells.CONCLUSION:The increase in cholesterol efflux by Aps might be related to the up-regulation of ABCA1.
