Acute stress affects the PRA and AngⅡ levels in plasma and the cytoskeletons in hippocampus in adult rats
- VernacularTitle:急性应激对成年鼠血浆肾素活性、AngⅡ水平和海马细胞骨架的影响
- Author:
Guogang SUN
;
Cehua OU
;
Bo CHEN
;
Yue CHEN
;
Guangbi FAN
- Publication Type:Journal Article
- Keywords:
Stress;
Renin;
Hippocampus;
Nestin;
Neurofilament proteins;
Rats
- From:
Chinese Journal of Pathophysiology
2000;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM:To observe the changes in plasma rennin activity(PRA)and angiotensin Ⅱ(AngⅡ)level and the cytoskeletons in dorsal hippocampus(DH)in male and female stressed rats.METHODS:The adult Sprague-Dawley male and femal rats were stressed for 6 h per day.Three days later,the levels of PRA and AngⅡin plasma were determined by radioimmunoassay,and the expression of nestin and NF200 in dentate gyrus(DG)and CA3 regions were observed with immunohistochemical staining.RESULTS:①The levels of PRA in plasma of male or female rats were decreased in stressed rats compared with control groups(P
