Expression of TNF-? in a rat model of chronic Pseudomonas aeruginosa biomembrane associated with lung infection
- VernacularTitle:大鼠慢性铜绿假单胞菌生物膜肺部感染TNF-?的测定及意义
- Author:
Ping YAN
;
Yiqiang CHEN
;
Jinliang KONG
;
Zhijun SONG
;
Hong WU
- Publication Type:Journal Article
- Keywords:
Pseudomonas,aeruginosa;
Biomembrane;
Lung infection;
Lung injury;
Tumor necrosis factor
- From:
Chinese Journal of Pathophysiology
2000;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM:To investigate the kinetics of tumor necrosis factor alpha(TNF-?)in an animal model of chronic P.aeruginosa biomembrane associated with lung infection.METHODS:Rats were challenged with 0.1 mL of PAO579(1012 CFU/L)in alginate beads or 0.1 mL of planktonic PAO579(1012 CFU/L).After challenging for 3,7 and 14 d,bacteriological and pathological features,and TNF-? expression in lung tissue were observed.RESULTS:(1)CFU/lung in alginate beads group was significantly higher than that in planktonic bacteria group(P
