Renal Excretion and Distribution of Platinum of 3 Kinds of Platinum Preparation in Rats:A Comparative Study
- VernacularTitle:大鼠静脉注射3种铂制剂后铂的肾排泄与肾分布比较研究
- Author:
Xiuqin LI
- Publication Type:Journal Article
- Keywords:
Dicycloplatin;
Carboplatin;
Cisplatin;
Renal excretion;
Renal tissue;
Concentration
- From:
China Pharmacy
2007;0(28):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study the mechanism of renal toxicity of platinums in rats.METHODS:A total of 12 rats were equally assigned to receive cisplatin,carboplatin,or dicycloplatin i.v with the dosage of platinum at 10 mg?kg-1.The cumulative excretion rate of platinum in urine in 4 h and the concentration of platinum in renal tissue were measured by atom absorption method.RESULTS:The total excretion percent of platinum in urine in the first 4 h after injection of cisplatin,carboplatin,and dicycloplatin were(33.7?5.7)%,(89.1?8.5)% and(70.1?9.8)% respectively.The renal platinum concentration were 70.6?31.6,217.7?97.6,and(278.8?112.0)?g?g-1,respectively.CONCLUSIONS:Both the renal excretion speed and renal concentrations of platinum were higher for dicycloplatin and carboplatin than for cisplatin.The nephrotoxicity of platinum drugs probably has no direct relationship with the renal concentration of platinum.
