Analyze of Uncertainty in the Determination of Azithromycin Granules by Microbiological Method
- VernacularTitle:微生物检定法测定阿奇霉素颗粒含量的不确定度分析
- Author:
Jin QIU
;
Qiang LI
- Publication Type:Journal Article
- Keywords:
Microbiological method;
Azithromycin granules;
Uncertainty analysis
- From:
China Pharmacy
2007;0(28):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To estimate the uncertainty in the content determination of azithromycin granules by microbiological method.METHODS:The origin and degree of uncertainty in the content determination of azithromycin granules by microbiological method were analyzed and evaluated in accordance with the standard given in JJF1059-1999 "Evaluation and Expression of Uncertainty in Measurement".RESULTS:The expanded uncertainty was 5 420.0 IU/bag,and the results of the determination can be expressed as(103 838.0?5 420.0)IU/bag.The uncertainty was chiefly originated from method design,followed by solution dilution.CONCLUSIONS:The degree of uncertainty for the content determination of antibiotic drugs by microbiological method can be effectively reduced by suitable method design and reducing the times of dilution.
