Comparison of 2 Kinds of Quantitative Analytical Methods on Dipyridamole
- VernacularTitle:双嘧达莫2种定量分析方法的比较
- Author:
Yi ZENG
- Publication Type:Journal Article
- Keywords:
Dipyridamole;
Nonaqueous titration;
HPLC;
Content determination
- From:
China Pharmacy
2007;0(28):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To validate the feasibility of nonaqueous perchloric acid titration and high performance liquid chromatography(HPLC)for the determination of the content of dipyridamole.METHODS:In the nonaqueous titration,the titration end-point was indicated potentiometrically,and the effects of different solvents on the titration were investigated.As to HPLC method,the separation of sample was performed on C18 column with the mobile phase consisted of acetonitrile-20 mmol?L-1 potassium dihydrogen phosphate(containing 1.0% triethylamine,adjusted pH to 4.0 with phosphoric acid,35∶65).The potassium bromate titration stated in Chinese Pharmacopoeia was taken as the reference.RESULTS:By nonaqueous titration,HPLC and potassium bromate method,the contents of dipyridamole were 101.36%,101.11% and 100.56%,respectively.CONCLUSIONS:Both nonaqueous titration and HPLC methods are suitable for the determination of the content of dipyridamole in its pharmaceutical products.Compared with potassium bromate titration,nonaqueous titration is more simple and convenient.
