Preparation and Encapsulation Efficiency Determination of Diclofenac Sodium Liposomes
- VernacularTitle:双氯芬酸钠脂质体的制备及包封率测定
- Author:
Mingzhi CAI
- Publication Type:Journal Article
- Keywords:
Diclofenac sodium liposomes;
HPLC;
Preparation;
Encapsulation efficiency
- From:
China Pharmacy
2007;0(28):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To prepare diclofenac sodium liposomes and establish a method for their quality control.METHODS:The diclofenac sodium liposomes were prepared by pH gradient method;the particle shape and size were measured by transmission electrical miscroscope;the concentration and encapsulation efficiency of diclofenac sodium in the liposomes were determined by HPLC.RESULTS:The prepared lipisomes were uniformly distributed with particle size of 150～175 nm.The linear range of diclofenac sodium was 0.01～1 mg?mL-1(r=0.999 0,n=6)at an average recovery of 100.05%(RSD=1.21%,n=6).The encapsulation efficiency ranged from 52.4% to 85.8%.CONCLUSION:High encapsulation efficiency of diclofenac sodium liposomes can be obtained from the established method.
