Validation of Microbial Limit Tests of Shuanghuanglian Oral Liquid
- VernacularTitle:双黄连口服液微生物限度检查法的验证
- Author:
Qinxin WANG
;
Jian ZHOU
- Publication Type:Journal Article
- Keywords:
Shuanghuanglian oral liquid;
Microbial limit test;
Membrane-filter procedure
- From:
China Pharmacy
2007;0(27):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To validate the microbial limit tests of Shuanghuanglian oral liquid.METHODS:The recovery rates of 4 kinds of test organisms including E.coli treated by Shuanghuanglian oral liquid were detected by routine method,culture medium dilution method,and membrane-filter procedure respectively.RESULTS:Shuanghuanglian oral liquid was found to be of bacteriostatic action.The contamination of solution couldn't be detected by routine method.The recovery rate of the test organisms detected by membrane-filter procedure was higher than by culture medium dilution method,but the recovery rates in both methods were all up to the requirement.CONCLUSION:Membrane-filter procedure should be considered preferentially in performing microbial limit test for Shuanghuanglian oral liquid.
