Effects of arachidonic acid on action potential and L-type calcium current in rabbit cardiomyocytes
- VernacularTitle:花生四烯酸对家兔心室肌细胞动作电位和L-型钙电流的影响
- Author:
Chengyun LIU
;
Guiqing CHEN
;
Xiaojing GENG
- Publication Type:Journal Article
- Keywords:
Arachidonic acid;
Ventricular myocytes;
Action potentials;
Calcium channels,L-type;
Patch-clamp techniques;
Rabbits
- From:
Chinese Journal of Pathophysiology
1999;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To study the influence of arachidonic acid(AA) on the action potential and L-type calcium current in rabbit cardiomyocytes.METHODS: Single ventricular myocyte was isolated using enzyme dispersion method.Whole-cell clamp-patch technique was used to record action potential and L-type calcium current.RESULTS: ① AA shortened action potential duration obviously,without marked effect on the resting potential and action potential amplitude.② AA reduced the current densities from(10.21?3.15)PA/PF to(6.53?2.17)PA/PF(n=6,P
