Influence of GPIF on the expression of costimulatory molecules lineaged T cells in mice with immunodeficiency in vivo
- VernacularTitle:GPIF对免疫损伤小鼠T淋巴细胞膜表面共刺激分子表达的影响
- Author:
Liaoqiong FANG
;
Xiaolan FU
;
Rong NIU
;
Xianwen JI
;
Hong WEI
- Publication Type:Journal Article
- Keywords:
Placenta;
Immunoregulating factors;
T-lymphocytes;
Cytokines
- From:
Chinese Journal of Pathophysiology
1999;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To investigate the effects of goat placenta immunoregulating factor(GPIF) on the expression of costimulatory molecules lineaged T cells in BALB/c mice.METHODS: Animal model for immunodeficiency made from BALB/c mice with whole-body irradiation by 5 Gy 60Co?-ray was applied for research.The immunosuppressive mice were injected with GPIF for seven days continuously.FACS was applied to analyze the rate of CD28+,CD152+,CD4+CD28+,CD8+CD28+,CD4+CD152+ and CD8+CD152+ cells in splenic lymphocytes and ELISA method was employed to measure the amount of IL-2 and IFN-? in serum of mice.RESULTS: GPIF increased the percentage of CD28+,CD4+CD28+ and CD8+CD28+ cells(P
