The role of glutamine and arginine in rat hepatic fibrosis
- VernacularTitle:谷氨酰胺和精氨酸对大鼠肝纤维化的影响
- Author:
Bo CHEN
;
Sheng HE
- Publication Type:Journal Article
- Keywords:
Hepatic Fibrosis/second;
Glutamine/adv eff;
Arginine;
Rats
- From:
Chinese Journal of General Surgery
2001;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect of glutamine and arginine in rats with hepatic fibrosis.Methods Thirty male Wistar rats with hepatic fibrosis induced by CCl4 for 6 weeks were randomly divided into control group(n=10)、glutamine treatment group(n=10) and arginine treatment group(n=10).At 8 weeks after treatment,the liver appearance、collagen protein level and the degree of hepatic fibrosis were observed.Results At the end of 8 weeks,there was no death of any group of the rats.The glutamine group showed the most severe hepatic fibrosis,the control group showed less,and the arginine group showed the least fibrosis.Conclusions The degree of hepatic fibrosis is aggravated by glutamine,while arginine obviously relieves rat hepatic fibrosis.
