Expression of LivinmRNA and Bcl-2,p53 proteins in pancreatic carcinoma
- VernacularTitle:LivinmRNA及Bcl-2,p53蛋白在胰腺癌中的表达
- Author:
Yuan LIU
;
Jie BAI
;
Donghua GENG
;
Jingang LIU
- Publication Type:Journal Article
- Keywords:
Pancreatic Neoplasm /genet;
Pancreatic Neoplasm /pathology;
Gene Expression
- From:
Chinese Journal of General Surgery
2001;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the expression of the apoptosis inhibitor Livin gene and its relationship with the expression of Bcl-2,p53 proteins in pancreatic carcinoma.Methods The expression of LivinmRNA was investigated by reverse transcriptase polymerase chain reaction(RT-PCR) in pancreatic carcinoma tissue of 52 cases and normal pancreatic tissue of 12 cases.The expression of Bcl-2 and p53 was detected by immunohistochemical assay.Results The expression rate of Livin gene in pancreatic carcinoma tissue was 71.2%,which was obviously higher than that in normal pancreatic tissue(P
